| Final 18:25 | time | | L | React. | | 1. Cuba | 3:28.09 | | 3 | 0.404 | | Aymee Martinez, Diosmely Pena, Susana Aylen Clement, Daysiurami Bonne | | 2. Brazil | 3:29.59 | | 8 | 0.242 | | Joelma Sousa, Geisa Coutinho, Barbara Oliveira, Jailma Lima | | 3. Colombia | 3:29.94 | NR | 4 | 0.210 | | Maria Princesa Oliveros, Norma Gonzalez, Evelis Jazmin Aguilar, Yenifer Padilla | | 4. United States | 3:33.42 | | 1 | 0.515 | | Ciara Elizabeth Short, Leslie Eugenia Cole, Takecia Ryelle Jameson, Mackenzie Mcclain Hill | | 5. Mexico | 3:40.07 | | 7 | 0.216 | | Karla Adriana Savinon, Gabriela Elizabeth Medina, Nallely Vela, Zudikey Rodriguez | | 6. Ecuador | 3:45.59 | NR | 6 | 0.605 | | Carla Pamela Chala, Celene Alejandra Cevallos, Erika Benilda Chavez, Luci Maria Del Carmen | | -. Dominicana | DNS | | 2 | | -. Jamaica | DNS | | 5 |
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| World Record: | | Soviet Union 3:15.17 | | Seoul (KOR), 01.10.1988 | | Panamerican Record: | | United States 3:23.35 | | | Indianapolis (USA), 16.08.1987 |
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